Two sample MR report
Type 2 diabetes || id:ieu-a-23 against Pancreatic cancer || id:ebi-a-GCST90018893
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 27 | 0.230 | 0.191 | 0.239 |
| Weighted median | 27 | 0.102 | 0.101 | 0.313 |
| Inverse variance weighted | 27 | 0.009 | 0.070 | 0.893 |
| Simple mode | 27 | 0.199 | 0.166 | 0.242 |
| Weighted mode | 27 | 0.140 | 0.123 | 0.264 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 23.3 | 25 | 0.560 |
| Inverse variance weighted | 24.9 | 26 | 0.527 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.027 | 0.022 | 0.225 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.148 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
