Two sample MR report
Type 2 diabetes || id:ieu-a-23 against Pancreatic cancer || id:ieu-a-822
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 21 | 0.425 | 0.505 | 0.410 |
| Weighted median | 21 | 0.012 | 0.166 | 0.944 |
| Inverse variance weighted | 21 | 0.027 | 0.117 | 0.818 |
| Simple mode | 21 | 0.060 | 0.297 | 0.841 |
| Weighted mode | 21 | 0.001 | 0.293 | 0.997 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.9 | 19 | 0.664 |
| Inverse variance weighted | 16.6 | 20 | 0.681 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.042 | 0.051 | 0.427 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.935 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
