Two sample MR report
Type 2 diabetes (adjusted for BMI) || id:ebi-a-GCST90093110 against hepatocellular carcinoma || id:bbj-a-158
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.262 | 0.473 | 0.592 |
| Weighted median | 12 | -0.109 | 0.146 | 0.454 |
| Inverse variance weighted | 12 | -0.158 | 0.107 | 0.139 |
| Simple mode | 12 | -0.280 | 0.230 | 0.250 |
| Weighted mode | 12 | -0.031 | 0.228 | 0.894 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.6 | 10 | 0.250 |
| Inverse variance weighted | 13.6 | 11 | 0.256 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.055 | 0.061 | 0.384 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.281 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
