Two sample MR report
Type 2 diabetes, definitions combined || id:finn-b-T2D against Colorectal cancer || id:ebi-a-GCST90018808
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 54 | -0.021 | 0.062 | 0.741 |
| Weighted median | 54 | -0.071 | 0.039 | 0.068 |
| Inverse variance weighted | 54 | -0.056 | 0.026 | 0.033 |
| Simple mode | 54 | 0.039 | 0.077 | 0.616 |
| Weighted mode | 54 | -0.095 | 0.046 | 0.046 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 76.5 | 52 | 0.015 |
| Inverse variance weighted | 77.1 | 53 | 0.017 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.004 | 0.006 | 0.525 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.507 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
