Two sample MR report
Type 2 diabetes, definitions combined || id:finn-b-T2D against Colorectal cancer || id:ieu-b-4965
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 50 | 0.002 | 0.001 | 0.085 |
| Weighted median | 50 | 0.001 | 0.001 | 0.363 |
| Inverse variance weighted | 50 | 0.001 | 0.001 | 0.239 |
| Simple mode | 50 | 0.001 | 0.001 | 0.385 |
| Weighted mode | 50 | 0.001 | 0.001 | 0.400 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 61.3 | 48 | 0.095 |
| Inverse variance weighted | 63.6 | 49 | 0.078 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.179 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.564 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
