Two sample MR report
Type 2 diabetes, definitions combined || id:finn-b-T2D against ER+ Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) || id:ieu-a-1127
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 47 | 0.116 | 0.056 | 0.045 |
| Weighted median | 47 | 0.015 | 0.026 | 0.564 |
| Inverse variance weighted | 47 | -0.016 | 0.026 | 0.539 |
| Simple mode | 47 | -0.015 | 0.055 | 0.792 |
| Weighted mode | 47 | 0.060 | 0.025 | 0.019 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 151 | 45 | 0 |
| Inverse variance weighted | 174 | 46 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.015 | 0.006 | 0.013 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.737 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
