Two sample MR report
Type 2 diabetes, definitions combined || id:finn-b-T2D against Liver & bile duct cancer || id:ieu-b-4915
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 43 | 0 | 0 | 0.529 |
| Weighted median | 43 | 0 | 0 | 0.422 |
| Inverse variance weighted | 43 | 0 | 0 | 0.996 |
| Simple mode | 43 | 0 | 0 | 0.785 |
| Weighted mode | 43 | 0 | 0 | 0.511 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 70.2 | 41 | 0.003 |
| Inverse variance weighted | 71.1 | 42 | 0.003 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0 | 0.483 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.579 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
