Two sample MR report
Type 2 diabetes, definitions combined || id:finn-b-T2D against Malignant neoplasm of liver and intrahepatic bile ducts (all cancers excluded) || id:finn-b-C3_LIVER_INTRAHEPATIC_BILE_DUCTS_EXALLC
Date: 02 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 42 | 0.177 | 0.806 | 0.827 |
| Weighted median | 42 | 0.016 | 0.278 | 0.953 |
| Inverse variance weighted | 42 | -0.012 | 0.276 | 0.966 |
| Simple mode | 42 | 0.248 | 0.619 | 0.691 |
| Weighted mode | 42 | 0.424 | 0.506 | 0.407 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 95.4 | 40 | 0 |
| Inverse variance weighted | 95.5 | 41 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.017 | 0.069 | 0.804 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.971 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
