Two sample MR report
Type 2 diabetes, definitions combined || id:finn-b-T2D against Pancreatic cancer || id:ebi-a-GCST90018893
Date: 01 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 54 | 0.071 | 0.131 | 0.587 |
| Weighted median | 54 | 0.159 | 0.092 | 0.083 |
| Inverse variance weighted | 54 | 0.098 | 0.059 | 0.098 |
| Simple mode | 54 | -0.014 | 0.160 | 0.932 |
| Weighted mode | 54 | 0.144 | 0.110 | 0.199 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 47.8 | 52 | 0.640 |
| Inverse variance weighted | 47.8 | 53 | 0.675 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.003 | 0.014 | 0.821 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.501 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
