

# Two sample MR report

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## Phosphatidylcholine (18:1_20:4) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   28| 0.5372211| 0.2675366| 0.0551356|
|Weighted median           |   28| 0.5020161| 0.2176915| 0.0211056|
|Inverse variance weighted |   28| 0.4147368| 0.1710348| 0.0153139|
|Simple mode               |   28| 0.7267701| 0.5479317| 0.1958221|
|Weighted mode             |   28| 0.5134497| 0.2193181| 0.0268590|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.90044|   26| 0.9385688|
|Inverse variance weighted | 16.25491|   27| 0.9479131|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0284027| 0.0477054| 0.5567381|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.015701|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_181204_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_181204_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_181204_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_181204_levels_against_finnbI9PVTEXNONEchunk8-1.png)
