

# Two sample MR report

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## Phosphatidylethanolamine (18:0_20:4) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   21| 0.9972952| 0.4233627| 0.0293866|
|Weighted median           |   21| 0.5165035| 0.2776682| 0.0628648|
|Inverse variance weighted |   21| 0.4920300| 0.1948569| 0.0115671|
|Simple mode               |   21| 0.9346377| 0.4330115| 0.0432242|
|Weighted mode             |   21| 0.5814094| 0.2898678| 0.0585981|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 20.11409|   19| 0.3877427|
|Inverse variance weighted | 22.00790|   20| 0.3400820|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1221012| 0.0912902| 0.1968493|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0051848|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylethanolamine_180204_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylethanolamine_180204_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylethanolamine_180204_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylethanolamine_180204_levels_against_finnbI9PVTEXNONEchunk8-1.png)
