

# Two sample MR report

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## Sterol ester (27:1/18:1) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   31|  0.4981097| 0.4814883| 0.3094431|
|Weighted median           |   31|  0.3811824| 0.3531459| 0.2804136|
|Inverse variance weighted |   31|  0.5805610| 0.2392903| 0.0152588|
|Simple mode               |   31| -0.1913640| 0.6946919| 0.7848468|
|Weighted mode             |   31| -0.0449997| 0.7214937| 0.9506817|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 29.61110|   29| 0.4336018|
|Inverse variance weighted | 29.65114|   30| 0.4836200|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0124913| 0.0630798| 0.844408|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004598|              0|TRUE                     |    0.0807099|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Sterol_ester_271181_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Sterol_ester_271181_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Sterol_ester_271181_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Sterol_ester_271181_levels_against_finnbI9PVTEXNONEchunk8-1.png)
