

# Two sample MR report

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## Triacylglycerol (54:3) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.1088157| 0.6216472| 0.8623046|
|Weighted median           |   30| -0.5007073| 0.3680908| 0.1737407|
|Inverse variance weighted |   30| -0.5568525| 0.2467171| 0.0240050|
|Simple mode               |   30| -1.4430595| 0.7588052| 0.0671796|
|Weighted mode             |   30| -0.3976752| 0.5161057| 0.4472175|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 32.00710|   28| 0.2742221|
|Inverse variance weighted | 32.71366|   29| 0.2894381|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0602778| 0.0766703| 0.438357|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0008281|              0|TRUE                     |    0.0190507|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_543_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_543_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_543_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_543_levels_against_finnbI9PVTEXNONEchunk8-1.png)
