

# Two sample MR report

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## Triacylglycerol (53:3) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   25| -0.1002471| 0.6133834| 0.8716051|
|Weighted median           |   25| -0.2376606| 0.3792869| 0.5309224|
|Inverse variance weighted |   25| -0.6358276| 0.2452684| 0.0095316|
|Simple mode               |   25| -1.2981564| 0.6892493| 0.0718151|
|Weighted mode             |   25| -0.1788361| 0.4607059| 0.7013058|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 20.01951|   23| 0.6407343|
|Inverse variance weighted | 20.92702|   24| 0.6430268|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0730564| 0.0766892| 0.3506824|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007823|              0|TRUE                     |     0.023048|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_533_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_533_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_533_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_533_levels_against_finnbI9PVTEXNONEchunk8-1.png)
