

# Two sample MR report

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## Phosphatidylinositol (16:0_18:2) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   23|  0.0097475| 0.6098000| 0.9873975|
|Weighted median           |   23| -0.5361352| 0.3526466| 0.1284309|
|Inverse variance weighted |   23| -0.5066672| 0.2399565| 0.0347297|
|Simple mode               |   23| -1.1479156| 0.7621944| 0.1462745|
|Weighted mode             |   23|  0.3894249| 0.5569930| 0.4917810|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.11447|   21| 0.8171647|
|Inverse variance weighted | 15.96303|   22| 0.8177164|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0741558| 0.0805013| 0.3674211|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0011935|              0|TRUE                     |    0.0052895|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylinositol_160182_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylinositol_160182_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylinositol_160182_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylinositol_160182_levels_against_finnbI9PVTEXNONEchunk8-1.png)
