

# Two sample MR report

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## Phosphatidylcholine (18:1_20:2) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   23| -0.8895285| 0.3549835| 0.0205181|
|Weighted median           |   23| -0.5396287| 0.2483379| 0.0297832|
|Inverse variance weighted |   23| -0.3854798| 0.1891061| 0.0415068|
|Simple mode               |   23| -0.0163610| 0.5421757| 0.9761983|
|Weighted mode             |   23| -0.5564762| 0.2504361| 0.0368774|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.26637|   21| 0.8093529|
|Inverse variance weighted | 18.08142|   22| 0.7011500|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.119535| 0.0712445| 0.1082057|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0085727|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_181202_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_181202_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_181202_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_181202_levels_against_finnbI9PVTEXNONEchunk8-1.png)
