

# Two sample MR report

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## Phosphatidylcholine (17:0_20:4) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.3972528| 0.3890172| 0.3540143|
|Weighted median           |    7| 0.4871082| 0.2086252| 0.0195514|
|Inverse variance weighted |    7| 0.4926806| 0.1945953| 0.0113472|
|Simple mode               |    7| 0.5439764| 0.5432028| 0.3552825|
|Weighted mode             |    7| 0.4942137| 0.2110937| 0.0577487|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.081675|    5| 0.4059940|
|Inverse variance weighted | 5.163690|    6| 0.5229968|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0408832| 0.1439189| 0.7877441|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0200655|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_170204_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_170204_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_170204_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_170204_levels_against_finnbI9PVTEXNONEchunk8-1.png)
