

# Two sample MR report

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## Phosphatidylcholine (16:0_20:4) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    7| 0.4408265| 0.2873207| 0.1855497|
|Weighted median           |    7| 0.4395323| 0.1866425| 0.0185256|
|Inverse variance weighted |    7| 0.3979757| 0.1788262| 0.0260485|
|Simple mode               |    7| 0.4125193| 0.4859087| 0.4284669|
|Weighted mode             |    7| 0.4369863| 0.1976372| 0.0690431|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.802655|    5| 0.8757216|
|Inverse variance weighted | 1.838962|    6| 0.9338974|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0180119| 0.0945289| 0.8563784|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0297069|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_160204_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_160204_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_160204_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_160204_levels_against_finnbI9PVTEXNONEchunk8-1.png)
