

# Two sample MR report

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## Triacylglycerol (56:3) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   24| -1.2497434| 0.6020819| 0.0498151|
|Weighted median           |   24| -0.3578519| 0.3432139| 0.2971105|
|Inverse variance weighted |   24| -0.5914193| 0.2427324| 0.0148299|
|Simple mode               |   24|  0.4289846| 0.7315026| 0.5632899|
|Weighted mode             |   24| -0.0695049| 0.5805557| 0.9057436|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 22.47447|   22| 0.4318923|
|Inverse variance weighted | 23.92776|   23| 0.4078179|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1079201| 0.0904817| 0.2456815|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0007347|              0|TRUE                     |    0.0394238|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Triacylglycerol_563_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Triacylglycerol_563_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Triacylglycerol_563_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Triacylglycerol_563_levels_against_finnbI9PVTEXNONEchunk8-1.png)
