

# Two sample MR report

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## Phosphatidylcholine (18:0_22:6) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|        b|        se|      pval|
|:-------------------------|----:|--------:|---------:|---------:|
|MR Egger                  |    3| 1.805535| 2.4002693| 0.5894301|
|Weighted median           |    3| 1.524198| 0.6119508| 0.0127484|
|Inverse variance weighted |    3| 1.398057| 0.5438205| 0.0101462|
|Simple mode               |    3| 1.601668| 0.7758353| 0.1750094|
|Weighted mode             |    3| 1.552681| 0.7304620| 0.1674325|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4514257|    1| 0.5016587|
|Inverse variance weighted | 0.4818047|    2| 0.7859184|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0558118| 0.3202125| 0.8901433|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002189|              0|TRUE                     |    0.2329723|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_180226_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_180226_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_180226_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_180226_levels_against_finnbI9PVTEXNONEchunk8-1.png)
