

# Two sample MR report

---

## Phosphatidylethanolamine (O-18:1_18:2) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   29| -0.2647464| 0.5775894| 0.6503588|
|Weighted median           |   29| -0.2381532| 0.3607631| 0.5091656|
|Inverse variance weighted |   29| -0.4916531| 0.2486265| 0.0479878|
|Simple mode               |   29|  0.2871498| 0.7797845| 0.7154619|
|Weighted mode             |   29|  0.2871498| 0.5927973| 0.6318711|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 29.37260|   27| 0.3430674|
|Inverse variance weighted | 29.58008|   28| 0.3835661|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0329149| 0.0753685| 0.665788|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006198|              0|TRUE                     |    0.0468892|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylethanolamine_O181182_levels_against_finnbI9PVTEXNONEchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylethanolamine_O181182_levels_against_finnbI9PVTEXNONEchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylethanolamine_O181182_levels_against_finnbI9PVTEXNONEchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylethanolamine_O181182_levels_against_finnbI9PVTEXNONEchunk8-1.png)
