

# Two sample MR report

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## Phosphatidylcholine (18:0_22:5) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 1.8842169| 0.6966963| 0.0538427|
|Weighted median           |    6| 0.8632496| 0.3796043| 0.0229613|
|Inverse variance weighted |    6| 0.8018271| 0.3378545| 0.0176303|
|Simple mode               |    6| 0.7627298| 0.7503541| 0.3560307|
|Weighted mode             |    6| 0.9067612| 0.3984638| 0.0719291|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.199804|    4| 0.6990651|
|Inverse variance weighted | 5.301407|    5| 0.3802138|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.2258322| 0.1282309| 0.1530137|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0016662|              0|TRUE                     |     0.001137|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_180225_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_180225_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_180225_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_180225_levels_against_finnbI9PVTEXNONEchunk8-1.png)
