

# Two sample MR report

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## Phosphatidylcholine (16:0_22:4) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.5861554| 0.7745222| 0.5281750|
|Weighted median           |    4| 0.9149297| 0.3615659| 0.0113912|
|Inverse variance weighted |    4| 0.8666442| 0.3486943| 0.0129407|
|Simple mode               |    4| 1.0418837| 0.5859270| 0.1734345|
|Weighted mode             |    4| 0.9258888| 0.3985504| 0.1027890|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.060011|    2| 0.5886017|
|Inverse variance weighted | 1.224499|    3| 0.7471347|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0615936| 0.1518691| 0.7243303|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0016648|              0|TRUE                     |    0.0010787|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_160224_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_160224_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_160224_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_160224_levels_against_finnbI9PVTEXNONEchunk8-1.png)
