

# Two sample MR report

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## Sterol ester (27:1/22:6) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    6|  1.6056378| 1.1231130| 0.2260413|
|Weighted median           |    6|  0.9993984| 0.4869135| 0.0401194|
|Inverse variance weighted |    6|  0.8317176| 0.3864743| 0.0313923|
|Simple mode               |    6| -0.1350854| 0.8766102| 0.8835579|
|Weighted mode             |    6|  1.3186821| 0.5551606| 0.0635326|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.010702|    4| 0.5560361|
|Inverse variance weighted | 3.549318|    5| 0.6159387|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.1512849| 0.2061369| 0.5037044|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004866|              0|TRUE                     |    0.0718971|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Sterol_ester_271226_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Sterol_ester_271226_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Sterol_ester_271226_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Sterol_ester_271226_levels_against_finnbI9PVTEXNONEchunk8-1.png)
