

# Two sample MR report

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## Phosphatidylcholine (O-18:1_20:4) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   22| 1.1586344| 0.5142070| 0.0356257|
|Weighted median           |   22| 0.9061801| 0.3520252| 0.0100475|
|Inverse variance weighted |   22| 0.5665230| 0.2467157| 0.0216611|
|Simple mode               |   22| 0.7445073| 0.6285802| 0.2494768|
|Weighted mode             |   22| 0.8634912| 0.3579318| 0.0250747|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.101435|   20| 0.9817023|
|Inverse variance weighted | 10.823924|   21| 0.9661069|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0833382| 0.0634989| 0.204236|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0017253|              0|TRUE                     |    0.0006884|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_O181204_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_O181204_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_O181204_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_O181204_levels_against_finnbI9PVTEXNONEchunk8-1.png)
