

# Two sample MR report

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## Phosphatidylcholine (O-16:0_22:5) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   17| 0.7104355| 0.6473843| 0.2897739|
|Weighted median           |   17| 0.5444471| 0.4259703| 0.2012022|
|Inverse variance weighted |   17| 0.6331894| 0.2993307| 0.0344001|
|Simple mode               |   17| 0.4194252| 0.7429089| 0.5801948|
|Weighted mode             |   17| 0.5578983| 0.6287218| 0.3880331|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.34872|   15| 0.7275055|
|Inverse variance weighted | 11.36683|   16| 0.7862972|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|      -0.0139799| 0.103887| 0.8947419|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0003961|              0|TRUE                     |    0.1359394|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_O160225_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_O160225_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_O160225_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_O160225_levels_against_finnbI9PVTEXNONEchunk8-1.png)
