

# Two sample MR report

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## Phosphatidylcholine (O-18:1_20:3) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -1.3480564| 0.8886255| 0.2685444|
|Weighted median           |    4| -0.9196103| 0.4066697| 0.0237395|
|Inverse variance weighted |    4| -0.9546070| 0.3770890| 0.0113570|
|Simple mode               |    4| -0.7873476| 0.6472382| 0.3107828|
|Weighted mode             |    4| -0.9087435| 0.4932220| 0.1626388|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.7557007|    2| 0.6853331|
|Inverse variance weighted | 0.9947928|    3| 0.8025119|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0756796| 0.1547733| 0.6732266|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.001044|              0|TRUE                     |    0.0098517|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_O181203_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_O181203_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_O181203_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_O181203_levels_against_finnbI9PVTEXNONEchunk8-1.png)
