

# Two sample MR report

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## Phosphatidylcholine (18:0_18:1) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.1067199| 0.6506630| 0.8708959|
|Weighted median           |   30|  0.6443347| 0.3739320| 0.0848644|
|Inverse variance weighted |   30|  0.5875315| 0.2755900| 0.0330147|
|Simple mode               |   30|  0.7488913| 0.7670488| 0.3369765|
|Weighted mode             |   30|  0.7293175| 0.7572812| 0.3434730|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 30.38619|   28| 0.3449987|
|Inverse variance weighted | 31.88750|   29| 0.3248332|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0902732| 0.0767509| 0.2494247|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002942|              0|TRUE                     |    0.1633224|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_180181_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_180181_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_180181_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_180181_levels_against_finnbI9PVTEXNONEchunk8-1.png)
