

# Two sample MR report

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## Phosphatidylcholine (16:0_16:0) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   25|  1.0690640| 0.7529988| 0.1690957|
|Weighted median           |   25|  0.5234607| 0.3794167| 0.1676957|
|Inverse variance weighted |   25|  0.6462287| 0.2611643| 0.0133455|
|Simple mode               |   25| -0.4241159| 0.7837327| 0.5933932|
|Weighted mode             |   25|  1.3253261| 0.6651165| 0.0577937|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 24.50993|   23| 0.3760378|
|Inverse variance weighted | 24.89334|   24| 0.4115754|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       -0.053348| 0.0889395| 0.5544882|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005006|              0|TRUE                     |    0.0683777|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_160160_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_160160_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_160160_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_160160_levels_against_finnbI9PVTEXNONEchunk8-1.png)
