

# Two sample MR report

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## Sterol ester (27:1/20:5) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.6642514| 0.4202659| 0.1891348|
|Weighted median           |    6| 0.6508967| 0.2677268| 0.0150490|
|Inverse variance weighted |    6| 0.6036601| 0.2531340| 0.0170910|
|Simple mode               |    6| 0.6508793| 0.6511960| 0.3634312|
|Weighted mode             |    6| 0.6508793| 0.2715729| 0.0618726|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 3.090260|    4| 0.5428358|
|Inverse variance weighted | 3.122881|    5| 0.6810478|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0161976| 0.0896821| 0.8654544|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0066474|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Sterol_ester_271205_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Sterol_ester_271205_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Sterol_ester_271205_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Sterol_ester_271205_levels_against_finnbI9PVTEXNONEchunk8-1.png)
