

# Two sample MR report

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## Sphingomyelin (d36:2) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   25| 0.4369897| 0.5696086| 0.4507812|
|Weighted median           |   25| 0.4746822| 0.3581319| 0.1850254|
|Inverse variance weighted |   25| 0.4973674| 0.2497708| 0.0464484|
|Simple mode               |   25| 0.8629585| 0.6497617| 0.1966329|
|Weighted mode             |   25| 0.9224645| 0.5825211| 0.1263809|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 22.50502|   23| 0.4899648|
|Inverse variance weighted | 22.51894|   24| 0.5483232|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0103048| 0.0873712| 0.9071374|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0006574|              0|TRUE                     |    0.0366098|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Sphingomyelin_d362_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Sphingomyelin_d362_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Sphingomyelin_d362_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Sphingomyelin_d362_levels_against_finnbI9PVTEXNONEchunk8-1.png)
