

# Two sample MR report

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## Diacylglycerol (16:0_18:2) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   28| -0.3166992| 0.5809938| 0.5903311|
|Weighted median           |   28| -0.2709999| 0.3568508| 0.4476009|
|Inverse variance weighted |   28| -0.7321539| 0.2599453| 0.0048540|
|Simple mode               |   28| -0.0614811| 0.7088501| 0.9315233|
|Weighted mode             |   28| -0.1233801| 0.5348157| 0.8192897|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 31.66829|   26| 0.2043175|
|Inverse variance weighted | 32.44961|   27| 0.2158418|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0627043| 0.0782904| 0.430437|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0005403|              0|TRUE                     |    0.0805232|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Diacylglycerol_160182_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Diacylglycerol_160182_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Diacylglycerol_160182_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Diacylglycerol_160182_levels_against_finnbI9PVTEXNONEchunk8-1.png)
