

# Two sample MR report

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## Phosphatidylcholine (20:4_0:0) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   25| 0.5161356| 0.2670294| 0.0656557|
|Weighted median           |   25| 0.4984433| 0.2160498| 0.0210506|
|Inverse variance weighted |   25| 0.4738651| 0.1680030| 0.0047938|
|Simple mode               |   25| 0.6525921| 0.5763549| 0.2687052|
|Weighted mode             |   25| 0.5201966| 0.2087124| 0.0199889|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 23.93203|   23| 0.4075801|
|Inverse variance weighted | 23.97637|   24| 0.4629495|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0109247| 0.0529257| 0.838282|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0194828|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_20400_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_20400_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_20400_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_20400_levels_against_finnbI9PVTEXNONEchunk8-1.png)
