

# Two sample MR report

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## Phosphatidylcholine (16:0_22:5) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   29| 0.5661573| 0.3323589| 0.0999691|
|Weighted median           |   29| 0.6334981| 0.2661553| 0.0173041|
|Inverse variance weighted |   29| 0.5133455| 0.1917102| 0.0074126|
|Simple mode               |   29| 0.6512814| 0.5467383| 0.2435704|
|Weighted mode             |   29| 0.6512814| 0.2772896| 0.0261262|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 21.35269|   27| 0.7694978|
|Inverse variance weighted | 21.39053|   28| 0.8086950|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0099936| 0.0513753| 0.8472233|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0070551|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_160225_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_160225_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_160225_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_160225_levels_against_finnbI9PVTEXNONEchunk8-1.png)
