

# Two sample MR report

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## Phosphatidylcholine (18:0_20:5) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.4758257| 0.4665393| 0.3828533|
|Weighted median           |    5| 0.6435606| 0.2701487| 0.0172074|
|Inverse variance weighted |    5| 0.7495671| 0.2540787| 0.0031763|
|Simple mode               |    5| 0.6300752| 0.6383126| 0.3794772|
|Weighted mode             |    5| 0.6356051| 0.2645639| 0.0741579|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.049361|    3| 0.5622251|
|Inverse variance weighted | 2.538799|    4| 0.6377020|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0854439| 0.1221328| 0.5345452|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0071001|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_180205_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_180205_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_180205_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_180205_levels_against_finnbI9PVTEXNONEchunk8-1.png)
