

# Two sample MR report

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## Phosphatidylcholine (18:0_20:2) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -1.4645890| 0.7694108| 0.3079428|
|Weighted median           |    3| -0.8429010| 0.3822677| 0.0274540|
|Inverse variance weighted |    3| -0.7754685| 0.3673394| 0.0347688|
|Simple mode               |    3| -0.5839150| 0.6711306| 0.4760068|
|Weighted mode             |    3| -0.9209850| 0.4144222| 0.1563386|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.2400671|    1| 0.6241576|
|Inverse variance weighted | 1.2790828|    2| 0.5275343|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.1419574| 0.1392666| 0.4939089|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0015445|              0|TRUE                     |    0.0037158|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_180202_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_180202_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_180202_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_180202_levels_against_finnbI9PVTEXNONEchunk8-1.png)
