

# Two sample MR report

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## Phosphatidylcholine (16:0_20:5) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    3| 0.3948899| 0.5399299| 0.5979921|
|Weighted median           |    3| 0.7682425| 0.3035206| 0.0113704|
|Inverse variance weighted |    3| 0.8245056| 0.2951410| 0.0052125|
|Simple mode               |    3| 1.0620520| 0.6312074| 0.2344863|
|Weighted mode             |    3| 0.7329399| 0.3124538| 0.1435980|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.6803828|    1| 0.4094550|
|Inverse variance weighted | 1.5832946|    2| 0.4530978|

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### Test for directional horizontal pleiotropy


| egger_intercept|      se|      pval|
|---------------:|-------:|---------:|
|       0.1262648| 0.13288| 0.5162475|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0044581|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylcholine_160205_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylcholine_160205_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylcholine_160205_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylcholine_160205_levels_against_finnbI9PVTEXNONEchunk8-1.png)
