

# Two sample MR report

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## Phosphatidylinositol (18:0_20:3) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   34| -0.9402654| 0.3724256| 0.0167345|
|Weighted median           |   34| -0.6301880| 0.2691358| 0.0192052|
|Inverse variance weighted |   34| -0.6199067| 0.1812994| 0.0006280|
|Simple mode               |   34| -0.6836669| 0.4898957| 0.1721747|
|Weighted mode             |   34| -0.6245038| 0.2713221| 0.0278021|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 32.17994|   32| 0.4578439|
|Inverse variance weighted | 33.15542|   33| 0.4596775|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0546059| 0.0554433| 0.3320635|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0042775|              0|TRUE                     |        2e-07|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Phosphatidylinositol_180203_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Phosphatidylinositol_180203_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Phosphatidylinositol_180203_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Phosphatidylinositol_180203_levels_against_finnbI9PVTEXNONEchunk8-1.png)
