

# Two sample MR report

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## Sterol ester (27:1/16:0) levels against finn-b-I9_PVT_EXNONE

Date: **16 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   34|  0.4684490| 0.3939550| 0.2431523|
|Weighted median           |   34|  0.5345698| 0.3018495| 0.0765638|
|Inverse variance weighted |   34|  0.4294977| 0.2011123| 0.0327111|
|Simple mode               |   34| -0.0795589| 0.6585618| 0.9045764|
|Weighted mode             |   34|  1.0492363| 0.4612945| 0.0295616|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 23.53269|   32| 0.8608303|
|Inverse variance weighted | 23.54591|   33| 0.8875970|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0062241| 0.0541303| 0.9091762|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0012396|              0|TRUE                     |    0.0040468|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Sterol_ester_271160_levels_against_finnbI9PVTEXNONEchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Sterol_ester_271160_levels_against_finnbI9PVTEXNONEchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Sterol_ester_271160_levels_against_finnbI9PVTEXNONEchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Sterol_ester_271160_levels_against_finnbI9PVTEXNONEchunk8-1.png)
