Two sample MR report
Phosphatidylcholine (18:0_22:5) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 1.8842169 | 0.6966963 | 0.0538427 |
| Weighted median | 6 | 0.8632496 | 0.3796043 | 0.0229613 |
| Inverse variance weighted | 6 | 0.8018271 | 0.3378545 | 0.0176303 |
| Simple mode | 6 | 0.7627298 | 0.7503541 | 0.3560307 |
| Weighted mode | 6 | 0.9067612 | 0.3984638 | 0.0719291 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.199804 | 4 | 0.6990651 |
| Inverse variance weighted | 5.301407 | 5 | 0.3802138 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2258322 | 0.1282309 | 0.1530137 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0016662 | 0 | TRUE | 0.001137 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
