Two sample MR report
Phosphatidylcholine (O-16:0_22:5) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.7104355 | 0.6473843 | 0.2897739 |
| Weighted median | 17 | 0.5444471 | 0.4259703 | 0.2012022 |
| Inverse variance weighted | 17 | 0.6331894 | 0.2993307 | 0.0344001 |
| Simple mode | 17 | 0.4194252 | 0.7429089 | 0.5801948 |
| Weighted mode | 17 | 0.5578983 | 0.6287218 | 0.3880331 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.34872 | 15 | 0.7275055 |
| Inverse variance weighted | 11.36683 | 16 | 0.7862972 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0139799 | 0.103887 | 0.8947419 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003961 | 0 | TRUE | 0.1359394 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
