Two sample MR report
Phosphatidylcholine (O-18:1_20:3) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -1.3480564 | 0.8886255 | 0.2685444 |
| Weighted median | 4 | -0.9196103 | 0.4066697 | 0.0237395 |
| Inverse variance weighted | 4 | -0.9546070 | 0.3770890 | 0.0113570 |
| Simple mode | 4 | -0.7873476 | 0.6472382 | 0.3107828 |
| Weighted mode | 4 | -0.9087435 | 0.4932220 | 0.1626388 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7557007 | 2 | 0.6853331 |
| Inverse variance weighted | 0.9947928 | 3 | 0.8025119 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0756796 | 0.1547733 | 0.6732266 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.001044 | 0 | TRUE | 0.0098517 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
