Two sample MR report
Phosphatidylcholine (O-18:1_20:4) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | 1.1586344 | 0.5142070 | 0.0356257 |
| Weighted median | 22 | 0.9061801 | 0.3520252 | 0.0100475 |
| Inverse variance weighted | 22 | 0.5665230 | 0.2467157 | 0.0216611 |
| Simple mode | 22 | 0.7445073 | 0.6285802 | 0.2494768 |
| Weighted mode | 22 | 0.8634912 | 0.3579318 | 0.0250747 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.101435 | 20 | 0.9817023 |
| Inverse variance weighted | 10.823924 | 21 | 0.9661069 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0833382 | 0.0634989 | 0.204236 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0017253 | 0 | TRUE | 0.0006884 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
