Two sample MR report
Phosphatidylinositol (16:0_18:2) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 23 | 0.0097475 | 0.6098000 | 0.9873975 |
| Weighted median | 23 | -0.5361352 | 0.3526466 | 0.1284309 |
| Inverse variance weighted | 23 | -0.5066672 | 0.2399565 | 0.0347297 |
| Simple mode | 23 | -1.1479156 | 0.7621944 | 0.1462745 |
| Weighted mode | 23 | 0.3894249 | 0.5569930 | 0.4917810 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.11447 | 21 | 0.8171647 |
| Inverse variance weighted | 15.96303 | 22 | 0.8177164 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0741558 | 0.0805013 | 0.3674211 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0011935 | 0 | TRUE | 0.0052895 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
