Two sample MR report
Sphingomyelin (d34:2) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | -0.7133208 | 1.0534375 | 0.5235544 |
| Weighted median | 8 | 0.7047838 | 0.4927412 | 0.1526216 |
| Inverse variance weighted | 8 | 0.8183605 | 0.3736871 | 0.0285270 |
| Simple mode | 8 | 0.0491949 | 0.8187553 | 0.9537673 |
| Weighted mode | 8 | 1.1022141 | 0.7086119 | 0.1637894 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.558339 | 6 | 0.6015701 |
| Inverse variance weighted | 6.976724 | 7 | 0.4313073 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2624364 | 0.1687568 | 0.1709173 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003382 | 0 | TRUE | 0.1338915 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
