Two sample MR report
Sphingomyelin (d36:2) levels against finn-b-I9_PVT_EXNONE
Date: 16 December, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 25 | 0.4369897 | 0.5696086 | 0.4507812 |
| Weighted median | 25 | 0.4746822 | 0.3581319 | 0.1850254 |
| Inverse variance weighted | 25 | 0.4973674 | 0.2497708 | 0.0464484 |
| Simple mode | 25 | 0.8629585 | 0.6497617 | 0.1966329 |
| Weighted mode | 25 | 0.9224645 | 0.5825211 | 0.1263809 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 22.50502 | 23 | 0.4899648 |
| Inverse variance weighted | 22.51894 | 24 | 0.5483232 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0103048 | 0.0873712 | 0.9071374 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006574 | 0 | TRUE | 0.0366098 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
