Two sample MR report
IL_12_P70 against phenotype
Date: 24 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.5073893 | 0.3084788 | 0.1310345 |
| Weighted median | 12 | -0.4042858 | 0.2078658 | 0.0517826 |
| Inverse variance weighted | 12 | -0.3692778 | 0.1786035 | 0.0386791 |
| Simple mode | 12 | -0.5025646 | 0.4881250 | 0.3253137 |
| Weighted mode | 12 | -0.4256418 | 0.2294562 | 0.0905726 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.181405 | 10 | 0.7997990 |
| Inverse variance weighted | 6.482935 | 11 | 0.8392796 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0276622 | 0.0503757 | 0.5949729 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0041225 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
