Two sample MR report
IL_13 against phenotype
Date: 24 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.4405748 | 0.3059817 | 0.1878630 |
| Weighted median | 10 | -0.3378737 | 0.1853247 | 0.0682814 |
| Inverse variance weighted | 10 | -0.3182766 | 0.1537716 | 0.0384709 |
| Simple mode | 10 | -0.0244980 | 0.3466425 | 0.9452042 |
| Weighted mode | 10 | -0.3208392 | 0.1996643 | 0.1425399 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.237743 | 8 | 0.3226390 |
| Inverse variance weighted | 9.492711 | 9 | 0.3930893 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0369682 | 0.0786726 | 0.6509701 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0061553 | 0 | TRUE | 3.7e-06 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
