Two sample MR report
MIF against phenotype
Date: 24 November, 2025
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.1892375 | 0.5056187 | 0.7235515 |
| Weighted median | 7 | -0.4936946 | 0.3638425 | 0.1748159 |
| Inverse variance weighted | 7 | -0.6000823 | 0.2623093 | 0.0221556 |
| Simple mode | 7 | -0.5025563 | 0.5583690 | 0.4027739 |
| Weighted mode | 7 | -0.4431754 | 0.5742556 | 0.4695633 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.464461 | 5 | 0.4846525 |
| Inverse variance weighted | 5.367852 | 6 | 0.4975702 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0918203 | 0.0966053 | 0.385521 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005014 | 0 | TRUE | 0.1921198 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
