

# Two sample MR report

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## ENSG00000197122 || id:eqtl-a-ENSG00000197122 against Liver cell carcinoma || id:ieu-b-4953

Date: **23 February, 2026**

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### Results from two sample MR:


|method                    | nsnp|  b| se|  pval|
|:-------------------------|----:|--:|--:|-----:|
|MR Egger                  |    9|  0|  0| 0.782|
|Weighted median           |    9|  0|  0| 0.359|
|Inverse variance weighted |    9|  0|  0| 0.301|
|Simple mode               |    9|  0|  0| 0.652|
|Weighted mode             |    9|  0|  0| 0.387|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 4.82|    7|  0.683|
|Inverse variance weighted | 4.88|    8|  0.771|

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### Test for directional horizontal pleiotropy


| egger_intercept| se|  pval|
|---------------:|--:|-----:|
|               0|  0| 0.809|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.079|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/ENSG00000197122__ideqtlaENSG00000197122_against_Liver_cell_carcinoma__idieub4953chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/ENSG00000197122__ideqtlaENSG00000197122_against_Liver_cell_carcinoma__idieub4953chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/ENSG00000197122__ideqtlaENSG00000197122_against_Liver_cell_carcinoma__idieub4953chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/ENSG00000197122__ideqtlaENSG00000197122_against_Liver_cell_carcinoma__idieub4953chunk8-1.png)
