

# Two sample MR report

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## C-C motif chemokine 19 levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   37| 0.1352147| 0.0551758| 0.0194012|
|Weighted median           |   37| 0.1335513| 0.0439003| 0.0023490|
|Inverse variance weighted |   37| 0.0749419| 0.0380845| 0.0490937|
|Simple mode               |   37| 0.1305356| 0.1245372| 0.3015486|
|Weighted mode             |   37| 0.1159099| 0.0432350| 0.0110079|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 39.39801|   35| 0.2795699|
|Inverse variance weighted | 41.88961|   36| 0.2305164|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       -0.010828| 0.007278| 0.1457662|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000656|              0|TRUE                     |    0.0031784|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/CC_motif_chemokine_19_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/CC_motif_chemokine_19_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/CC_motif_chemokine_19_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/CC_motif_chemokine_19_levels_against_gastriccancerchunk8-1.png)
