

# Two sample MR report

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## Fibroblast growth factor 5 levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   34| -0.0002049| 0.0385351| 0.9957903|
|Weighted median           |   34| -0.0525569| 0.0325500| 0.1063865|
|Inverse variance weighted |   34| -0.0612957| 0.0304453| 0.0440823|
|Simple mode               |   34| -0.1931951| 0.1099562| 0.0881905|
|Weighted mode             |   34| -0.0546339| 0.0308420| 0.0857283|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 33.29128|   32| 0.4042087|
|Inverse variance weighted | 39.08051|   33| 0.2153877|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       -0.016265| 0.006895| 0.0245968|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0169485|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Fibroblast_growth_factor_5_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Fibroblast_growth_factor_5_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Fibroblast_growth_factor_5_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Fibroblast_growth_factor_5_levels_against_gastriccancerchunk8-1.png)
