

# Two sample MR report

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## Axin-1 levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   13| -0.1196025| 0.2766805| 0.6738925|
|Weighted median           |   13|  0.0689125| 0.1148181| 0.5483804|
|Inverse variance weighted |   13|  0.2038181| 0.0834557| 0.0145968|
|Simple mode               |   13|  0.0907582| 0.2205259| 0.6879223|
|Weighted mode             |   13|  0.0477634| 0.1141659| 0.6830677|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  |  9.195861|   11| 0.6038190|
|Inverse variance weighted | 10.699023|   12| 0.5548733|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0290473| 0.0236921| 0.245785|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         4.6e-05|              0|TRUE                     |    0.4750217|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Axin1_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Axin1_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Axin1_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Axin1_levels_against_gastriccancerchunk8-1.png)
