

# Two sample MR report

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## Neurturin levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   25|  0.0059771| 0.2321523| 0.9796818|
|Weighted median           |   25| -0.3646466| 0.1205781| 0.0024933|
|Inverse variance weighted |   25| -0.2651777| 0.0859775| 0.0020405|
|Simple mode               |   25| -0.3739489| 0.1831152| 0.0522726|
|Weighted mode             |   25| -0.3919627| 0.1222659| 0.0037869|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 24.01173|   23| 0.4031590|
|Inverse variance weighted | 25.65626|   24| 0.3708338|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       -0.023012| 0.018335| 0.2220519|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.25e-05|              0|TRUE                     |    0.3607043|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Neurturin_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Neurturin_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Neurturin_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Neurturin_levels_against_gastriccancerchunk8-1.png)
