

# Two sample MR report

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## Tumor necrosis factor ligand superfamily member 12 levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   44| -0.3049224| 0.1201835| 0.0149783|
|Weighted median           |   44| -0.1282578| 0.0817485| 0.1166641|
|Inverse variance weighted |   44| -0.1210728| 0.0518950| 0.0196464|
|Simple mode               |   44|  0.1675703| 0.1292512| 0.2017285|
|Weighted mode             |   44| -0.0871387| 0.0772012| 0.2652733|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 48.42376|   42| 0.2296560|
|Inverse variance weighted | 51.70906|   43| 0.1702632|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0172819| 0.0102379| 0.0988165|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0004811|              0|TRUE                     |    0.0111292|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Tumor_necrosis_factor_ligand_superfamily_member_12_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Tumor_necrosis_factor_ligand_superfamily_member_12_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Tumor_necrosis_factor_ligand_superfamily_member_12_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Tumor_necrosis_factor_ligand_superfamily_member_12_levels_against_gastriccancerchunk8-1.png)
