

# Two sample MR report

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## Interleukin-1-alpha levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   25| 0.1825401| 0.0744405| 0.0222104|
|Weighted median           |   25| 0.1303738| 0.0578368| 0.0241857|
|Inverse variance weighted |   25| 0.0856665| 0.0404912| 0.0343719|
|Simple mode               |   25| 0.0675107| 0.0864908| 0.4426963|
|Weighted mode             |   25| 0.1101374| 0.0524879| 0.0465811|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 15.65306|   23| 0.8697136|
|Inverse variance weighted | 18.05820|   24| 0.8001761|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0159306| 0.0102722| 0.1345896|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000247|              0|TRUE                     |    0.1066099|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin1alpha_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin1alpha_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin1alpha_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin1alpha_levels_against_gastriccancerchunk8-1.png)
