

# Two sample MR report

---

## Leukemia inhibitory factor receptor levels against gastric_cancer

Date: **02 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.3019551| 0.0778823| 0.0005837|
|Weighted median           |   30| -0.2198291| 0.0633896| 0.0005245|
|Inverse variance weighted |   30| -0.1204267| 0.0418013| 0.0039650|
|Simple mode               |   30| -0.0497996| 0.1312869| 0.7072148|
|Weighted mode             |   30| -0.2241420| 0.0564636| 0.0004344|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 21.88391|   28| 0.7866372|
|Inverse variance weighted | 29.46626|   29| 0.4409900|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0235466| 0.0085512| 0.0102339|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0009734|              0|TRUE                     |     0.001107|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Leukemia_inhibitory_factor_receptor_levels_against_gastriccancerchunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Leukemia_inhibitory_factor_receptor_levels_against_gastriccancerchunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Leukemia_inhibitory_factor_receptor_levels_against_gastriccancerchunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Leukemia_inhibitory_factor_receptor_levels_against_gastriccancerchunk8-1.png)
