

# Two sample MR report

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## Tumor necrosis factor receptor superfamily member 9 levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   39|  0.0457055| 0.1395036| 0.7450385|
|Weighted median           |   39| -0.0701541| 0.0666372| 0.2924431|
|Inverse variance weighted |   39| -0.1537667| 0.0501266| 0.0021581|
|Simple mode               |   39| -0.1679610| 0.1086674| 0.1304794|
|Weighted mode             |   39| -0.1148239| 0.0681198| 0.1000657|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 44.06556|   37| 0.1974796|
|Inverse variance weighted | 46.84750|   38| 0.1537397|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0219492| 0.0143613| 0.1349286|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0002146|              0|TRUE                     |    0.1359871|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Tumor_necrosis_factor_receptor_superfamily_member_9_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Tumor_necrosis_factor_receptor_superfamily_member_9_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Tumor_necrosis_factor_receptor_superfamily_member_9_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Tumor_necrosis_factor_receptor_superfamily_member_9_levels_against_gastriccancerchunk8-1.png)
