

# Two sample MR report

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## Interleukin-6 levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   13| 0.0670585| 0.1032434| 0.5293325|
|Weighted median           |   13| 0.1307462| 0.0731973| 0.0740646|
|Inverse variance weighted |   13| 0.1282484| 0.0594183| 0.0308968|
|Simple mode               |   13| 0.1112935| 0.1011137| 0.2926268|
|Weighted mode             |   13| 0.1112935| 0.0685948| 0.1306624|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 8.808764|   11| 0.6395391|
|Inverse variance weighted | 9.333995|   12| 0.6741690|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0091192| 0.012583| 0.4837497|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000206|              0|TRUE                     |    0.0971913|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin6_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin6_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin6_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin6_levels_against_gastriccancerchunk8-1.png)
