

# Two sample MR report

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## Interleukin-17A levels against gastric_cancer

Date: **02 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   24| -0.0963863| 0.1995623| 0.6338755|
|Weighted median           |   24| -0.2103676| 0.1031345| 0.0413762|
|Inverse variance weighted |   24| -0.1909429| 0.0712632| 0.0073753|
|Simple mode               |   24|  0.2798132| 0.1487375| 0.0726559|
|Weighted mode             |   24| -0.2516178| 0.1069174| 0.0275236|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 19.57979|   22| 0.6093063|
|Inverse variance weighted | 19.83711|   23| 0.6517170|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|      -0.0091695| 0.0180762| 0.617016|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.41e-05|              0|TRUE                     |    0.3428802|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin17A_levels_against_gastriccancerchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin17A_levels_against_gastriccancerchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin17A_levels_against_gastriccancerchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin17A_levels_against_gastriccancerchunk8-1.png)
