Two sample MR report
Tumor necrosis factor ligand superfamily member 12 levels against gastric_cancer
Date: 02 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 44 | -0.3049224 | 0.1201835 | 0.0149783 |
| Weighted median | 44 | -0.1282578 | 0.0817485 | 0.1166641 |
| Inverse variance weighted | 44 | -0.1210728 | 0.0518950 | 0.0196464 |
| Simple mode | 44 | 0.1675703 | 0.1292512 | 0.2017285 |
| Weighted mode | 44 | -0.0871387 | 0.0772012 | 0.2652733 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 48.42376 | 42 | 0.2296560 |
| Inverse variance weighted | 51.70906 | 43 | 0.1702632 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0172819 | 0.0102379 | 0.0988165 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004811 | 0 | TRUE | 0.0111292 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
